Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution.
نویسندگان
چکیده
The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 88 شماره
صفحات -
تاریخ انتشار 2013